Roundup-induced biochemical and histopathological changes in the liver and kidney of rats: the ameliorative effects of Linum usitatissimum oil
| Autor: | Lynda Sabrina Ounaceur, Faiza Taibi, Mahieddine Boumendjel, Hichem Amara, Taha Khaldi, Amel Boumendjel, Baya Nouha Moubine, Mahfoud Messarah, Mereim Rouag, Nesrine Djaber, Salma Berrouague |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Linseed Oil Antioxidant DPPH Bilirubin medicine.medical_treatment Glycine Kidney Protective Agents medicine.disease_cause Antioxidants General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Flax Internal medicine medicine Animals IC50 Creatinine Chemistry Rats Oxidative Stress Endocrinology Liver Toxicity Urea Biomarkers Oxidative stress |
| Zdroj: | Acta Biochimica Polonica. |
| ISSN: | 1734-154X 0001-527X |
| DOI: | 10.18388/abp.2020_2898 |
| Popis: | The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of LuO) and RDP+LuO group (RDP and LuO simultaneously). LuO decreased the ferric reducing antioxidant power (FRAP) (IC50=10.36 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50=22.85 mg/ml) in the tested tissues. The 30-day exposure of rats to RDP caused an increase in serum hepatic and renal markers: AST, ALT, ALP, LDH, γGT, bilirubin, urea, and creatinine. In addition, SOD, CAT and GST activities decreased by 43%, 61%, and 61%, respectively, while GPx activity, MDA and PCOs levels increased by 80%, 46%, 25%, respectively. LuO treatment alleviated hepatotoxicity in RDP-treated rats, showing improved levels of oxidative stress biomarkers and plasma biochemical parameters. The histological examination of the liver and kidney confirmed the changes in Roundup-treated rats and demonstrated the protective role of LuO. |
| Databáze: | OpenAIRE |
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