The multifaceted roles of NUCLEAR FACTOR-Y in Arabidopsis thaliana development and stress responses
Autor: | Swadhin Swain, Ben F. Holt, Chamindika L. Siriwardana, Zachary A. Myers |
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Rok vydání: | 2017 |
Předmět: |
0106 biological sciences
0301 basic medicine Transcription Genetic ved/biology.organism_classification_rank.species Arabidopsis Biophysics Context (language use) Computational biology Biology Bioinformatics 01 natural sciences Biochemistry Genome 03 medical and health sciences Gene Expression Regulation Plant Stress Physiological Structural Biology Heterotrimeric G protein Genetics Arabidopsis thaliana Model organism Molecular Biology Transcription factor Arabidopsis Proteins ved/biology Promoter biology.organism_classification 030104 developmental biology CCAAT-Binding Factor 010606 plant biology & botany |
Zdroj: | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1860:636-644 |
ISSN: | 1874-9399 |
Popis: | NUCLEAR FACTOR-Y (NF-Y) is a heterotrimeric transcription factor (TF) consisting of evolutionarily distinct NF-YA, NF-YB and NF-YC subunits. The functional NF-Y heterotrimer binds to CCAAT elements in eukaryotic gene promoters and influences their expression. The genome of the model organism Arabidopsis thaliana encodes 10 distinct NF-YA, NF-YB, and NF-YC proteins, allowing for enormous combinatorial and functional diversity. Two decades of research have elucidated the importance of NF-Ys in plant growth, development and stress responses; however, the molecular mechanisms of action remain largely unexplored. Intriguingly, recent evidence suggests that NF-Ys are frequently associated with other groups of TFs, expanding the potential NF-Y combinatorial complexity. Further, information regarding the regulation of individual NF-Y subunits at the transcriptional and post-transcriptional level is beginning to emerge. In this review, we will identify developing trends within the NF-Y field and discuss recent progress towards a better understanding of NF-Y function, molecular action, and regulation in the context of Arabidopsis. This article is part of a Special Issue entitled: Nuclear Factor Y in Development and Disease, edited by Prof. Roberto Mantovani. |
Databáze: | OpenAIRE |
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