Transfusion-related acute lung injury (TRALI) during remission induction course of acute myeloid leukemia: a possible role for all-transretinoic-acid (ATRA)?
| Autor: | Ramzi Jeddi, Zaher Belhadjali, Balkis Meddeb, Hela Ben Abid, Emna Gouider, Karima Kacem, R. Mansouri |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Leukocytosis Antineoplastic Agents Tretinoin Lung injury medicine Humans Diffuse alveolar damage Respiratory Distress Syndrome Respiratory distress business.industry Respiratory disease Remission Induction Myeloid leukemia Transfusion Reaction Anemia General Medicine medicine.disease Pulmonary edema Flow Cytometry Leukemia Leukemia Myeloid Acute Immunology Female business Transfusion-related acute lung injury |
| Zdroj: | Pathologie-biologie. 57(6) |
| ISSN: | 1768-3114 |
| Popis: | Transfusion-related acute lung injury (TRALI) is a clinical syndrome characterized by sudden onset of respiratory distress due to pulmonary edema during or following transfusion. Two proposed pathophysiologic mechanisms for TRALI were proposed: the antibody hypothesis and the two-event hypothesis. The two-event hypothesis postulates that a pathway to neutrophil activation and aggregation can occur without leukocyte antibodies. We report a case of TRALI occurring during remission induction course of acute myeloid leukemia in a 27-year-old woman who received All-transretinoic-acid (ATRA). We postulate that ATRA may have played a role in this life-threatening complication by priming neutrophil and enhancing their adherence and their activation in the pulmonary endothelium. TRALI improved with non-invasive ventilation support and use of high dose corticosteroids. |
| Databáze: | OpenAIRE |
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