Peptide T improves psoriasis when infused into lesions in nanogram amounts
| Autor: | Ellis N. Cohen, Eugene M. Farber, Daniel J. Trozak, David I. Wilkinson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Time Factors Biopsy medicine.medical_treatment Peptide Dermatology Injections Intralesional Sodium Chloride Gastroenterology Placebos chemistry.chemical_compound Double-Blind Method Internal medicine Psoriasis medicine Humans Peptide T amide Saline Infusion Pumps chemistry.chemical_classification Chemotherapy medicine.diagnostic_test business.industry Peptide T Equipment Design Middle Aged medicine.disease chemistry Female business |
| Zdroj: | Journal of the American Academy of Dermatology. 25:658-664 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/0190-9622(91)70249-2 |
| Popis: | In each of 14 patients, two small but comparable psoriatic lesions were infused for 2 weeks with either saline or a saline solution of peptide T (as its analog D-ala1-peptide T amide) at 10(-7) mol/L with Alzet osmotic pumps worn extracorporeally. During infusion, lesions were photographed and scored for clinical features of psoriasis on a 9-point scale. After another 7 days, biopsy specimens were taken from the infused sites, and sections were scored for features of psoriasis on a 19-point scale. The differences between means for data from saline- and peptide T-infused lesions were evaluated statistically. Peptide T-infused lesions improved clinically; scores decreased from a mean of 4.35 initially to 1.57 at biopsy, whereas control lesions changed from 4.43 to 3.57 (p less than 0.01 for 1.57 vs 3.57). Histologic scores were also significantly different (5.28 for peptide T vs 10.00 for controls, 0.05 greater than p greater than 0.02). This study provides evidence that intralesionally infused peptide T demonstrates some clearing effect in psoriasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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