Explicit disassociation of a conditioned stimulus and unconditioned stimulus during extinction training reduces both time to asymptotic extinction and spontaneous recovery of a conditioned taste aversion
| Autor: | Jennifer Huffman, Jaclyn M. Biada, Zana Hoxha, Ye-Hyun Kim, Stephanie Bacik, Anthony DiSorbo, G. Andrew Mickley, Gina N. Wilson |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Taste
Health (social science) Spontaneous recovery Classical conditioning Experimental and Cognitive Psychology Extinction (psychology) Article Education chemistry.chemical_compound Neuropsychology and Physiological Psychology chemistry Anesthesia Developmental and Educational Psychology Taste aversion Conditioning Fear conditioning Psychology Saccharin Neuroscience psychological phenomena and processes |
| Popis: | Conditioned taste aversions (CTAs) may be acquired when an animal consumes a novel taste (CS) and then experiences the symptoms of poisoning (US). This aversion may be extinguished by repeated exposure to the CS alone. However, following a latency period in which the CS is not presented, the CTA will spontaneously recover (SR). In the current study we employed an explicitly unpaired extinction procedure (EU-EXT) to determine if it could thwart SR of a CTA. Sprague–Dawley rats acquired a strong CTA after three pairings of saccharin (SAC the CS) and Lithium Chloride (LiCl the US). CTA acquisition was followed by extinction (EXT) training consisting of either (a) CS-only exposure (CSO) or (b) exposure to saccharin and Lithium Chloride on alternate days (i.e., explicitly unpaired: EU). Both extinction procedures resulted in ⩾90% reacceptance of SAC, although the EU extinction procedure (EU-EXT) significantly decreased the time necessary for rats to reach this criterion (compared to CSO controls). Rats were subsequently tested for SR of the CTA upon re-exposure to SAC following a 30-day latency period of water drinking. Rats that acquired a CTA and then underwent the CSO extinction procedure exhibited a significant suppression of SAC drinking during the SR test (as compared to their SAC drinking at the end of extinction). However, animals in the EU-EXT group did not show such suppression in drinking compared to CSO controls. These data suggest that the EU-EXT procedure may be useful in reducing both time to extinction and the spontaneous recovery of fears. |
| Databáze: | OpenAIRE |
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