Estrogen-dependent effect of soy extract on pentylenetetrazole-induced seizures in rats
| Autor: | Mahmoud Hosseini, Hamid Reza Sadeghnia, Toktam Mohammadpour, Ebrahimzadeh Bideskan Ar, Reza Karami, Lili Enayatfard |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Ovariectomy Clonic seizure Phytoestrogens Body weight chemistry.chemical_compound Seizures Internal medicine medicine Animals Ketamine Rats Wistar Saline business.industry Plant Extracts Rats Endocrinology Complementary and alternative medicine chemistry Estrogen Ovariectomized rat Pentylenetetrazole Anticonvulsants Female Soybeans business medicine.drug Hormone |
| Zdroj: | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 10(12) |
| ISSN: | 1672-1977 |
| Popis: | OBJECTIVE To study the different effects of soy extract on pentylenetetrazole (PTZ)-induced seizures in the presence and absence of ovarian hormones in rats, and the gender-dependent differences in the effects of phytoestrogens on behavior. METHODS Male and female Wistar rats were randomly divided into nine groups with eight in each, namely, male-saline (M-saline), male-low-dose soy (M-LDS), male-high-dose soy (M-HDS), sham-saline (Sh-saline), sham-low-dose soy (Sh-LDS), sham-high-dose soy (Sh-HDS), ovariectomized-saline (OVX-saline), ovariectomized-low-dose soy (OVX-LDS) and ovariectomized-high-dose soy (OVX-HDS). The rats of groups 7 to 9 were ovariectomized under ketamine anesthesia. The rats of groups 2, 5 and 8 were treated by 20 mg/kg of soy extract while the animals of groups 3, 6 and 9 received 60 mg/kg of soy extract for two weeks. In groups 1, 4 and 7, saline was injected instead of soy extract. The animals were then injected by a single dose of PTZ (90 mg/kg body weight, intraperitoneally) and placed in a plexiglas cage and the latency to minimal clonic seizure (MCS) and generalized tonic-clonic seizure (GTCS) was recorded. RESULTS Both MCS and GTCS latency in M-LDS and M-HDS groups was significantly lower than that in M-saline group (P |
| Databáze: | OpenAIRE |
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