Plasma profile of Cimicoxib in sheep after oral administration at two different rates
| Autor: | Cristina Vercelli, M Trabalza Marinucci, Mario Giorgi, H. K. Lee, A. Di Salvo, Fabrizio Rueca, G. della Rocca |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oral treatment
sheep 040301 veterinary sciences cimicoxib oral administration pharmacokinetics Veterinary (all) Administration Oral Absorption (skin) Cimicoxib 0403 veterinary science chemistry.chemical_compound Random Allocation Animal science Pharmacokinetics Oral administration Medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Sulfonamides General Veterinary Dose-Response Relationship Drug business.industry 05 social sciences Imidazoles 04 agricultural and veterinary sciences General Medicine chemistry Area Under Curve Plasma concentration Female Dose rate business After treatment |
| Popis: | Sheep are often subjected to painful procedures and thus they need to be treated with analgesics. Nevertheless, knowledges about pharmacokinetic features of these drugs in this species are poor. The aim of this study was to evaluate plasma behaviour of cimicoxib in sheep after a single oral administration at two different dose rates (4 and 6 mg/kg). Maximum plasma concentrations of cimicoxib were equal to 273.78 (median value; range 189.00-567.32) and 565.01 (range 308.27-822.59) ng/mL after treatment with 4 and 6 mg/kg, respectively. The time of maximum concentration (Tmax) was achieved between 4 and 10 hours following treatment at the lower dose, and between 6 and 10 hours after the administration of the higher dose, with one sheep achieving the concentration peak at 0.75 hours. The slow absorption and the great individual variability in plasma concentration, probably due to ruminal effects, suggest that cimicoxib is not suitable for oral treatment in sheep. |
| Databáze: | OpenAIRE |
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