Minimal injection site pain and high patient satisfaction during treatment with long-acting risperidone
| Autor: | Kathleen Jarboe, Robert A. Lasser, Cynthia A. Bossie, Jean-Pierre Lindenmayer, Young Zhu, Angelika Mehnert |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.drug_class Visual analogue scale Injections Subcutaneous medicine.medical_treatment Pain Atypical antipsychotic law.invention Placebos Patient satisfaction Double-Blind Method Randomized controlled trial law medicine Humans Pharmacology (medical) Antipsychotic Risperidone business.industry Dopamine antagonist Clinical trial Psychiatry and Mental health Patient Satisfaction Delayed-Action Preparations Anesthesia Schizophrenia Patient Compliance Female business medicine.drug |
| Zdroj: | International Clinical Psychopharmacology. 20:213-221 |
| ISSN: | 0268-1315 |
| DOI: | 10.1097/00004850-200507000-00004 |
| Popis: | Long-acting injectable antipsychotic formulations of conventional antipsychotics were developed to address the problem of partial adherence among patients with schizophrenia. Injection site pain, other skin reactions and patient satisfaction with treatment were assessed in two large, multicentre studies of long-acting injectable risperidone (Risperdal CONSTA, Janssen Pharmaceutica Products, Titusville, New Jersey, USA), the first available long-acting atypical antipsychotic agent. Patients rated injection site pain using a 100-mm Visual Analogue Scale (VAS), and investigators rated injection site pain, redness, swelling and induration. Patient satisfaction with treatment was assessed with the Drug Attitude Inventory (DAI). VAS pain ratings were low at all visits across all doses in both studies, and decreased from first to final injection. In the 12-week, double-blind study, mean +/- SD VAS scores at the first and final injections were 15.6 +/- 20.7 and 12.5 +/- 18.3 for placebo-treated patients, and 11.8 +/- 14.4 (first) and 10.0 +/- 12.4 (final) for 25 mg; 16.3+/-21.9 (first) and 13.6 +/- 21.7 (final) for 50 mg; and 16.0 +/- 17.9 (first) and 9.6 +/- 16.0 (final, P |
| Databáze: | OpenAIRE |
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