Metabolic Regulation of Thymic Epithelial Cell Function
| Autor: | Ann V. Griffith, Nicholas E. Jones, Manpreet K. Semwal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
thymic stromal cells lcsh:Immunologic diseases. Allergy Stromal cell Mini Review T cell Immunology Thymus Gland Biology 03 medical and health sciences 0302 clinical medicine Immune system thymus medicine Autophagy Immunology and Allergy Animals Humans Progenitor cell PI3K/AKT/mTOR pathway tolerance TOR Serine-Threonine Kinases Epithelial Cells T lymphocyte Cell biology Oxidative Stress 030104 developmental biology medicine.anatomical_structure Phenotype Cellular Microenvironment mTOR lcsh:RC581-607 Energy Metabolism Reactive Oxygen Species 030217 neurology & neurosurgery Intracellular Signal Transduction |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| Popis: | The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stromal cells, including thymic epithelial cells (TECs) are critical for the development of T cell-mediated immunity, many aspects of their basic biology have been difficult to resolve because they represent a small fraction of thymus cellularity, and because their isolation requires enzymatic digestion that induces broad physiological changes. These obstacles are especially relevant to the study of metabolic regulation of cell function, since isolation procedures necessarily disrupt metabolic homeostasis. In contrast to the well-characterized relationships between metabolism and intracellular signaling in T cell function during an immune response, metabolic regulation of thymic stromal cell function represents an emerging area of study. Here, we review recent advances in three distinct, but interconnected areas: regulation of mTOR signaling, reactive oxygen species (ROS), and autophagy, with respect to their roles in the establishment and maintenance of the thymic stromal microenvironment. |
| Databáze: | OpenAIRE |
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