Low Particulate Type IV Phosphodiesterase Activity in Hypothyroid Rat Atria
| Autor: | Allen Kaasik, Ville-Veikko Elomaa, Jorma J. Ohisalo, Enn K. Seppet |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Heart Ventricles Adrenergic Adipose tissue Contractility 03 medical and health sciences 0302 clinical medicine Hypothyroidism Internal medicine medicine Animals Heart Atria Particle Size Rats Wistar Molecular Biology Rolipram Rat atria 030304 developmental biology 0303 health sciences Phosphoric Diester Hydrolases Chemistry Thyroid Rats Isoenzymes medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis cardiovascular system Propylthiouracil Phosphodiesterase activity Cardiology and Cardiovascular Medicine hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Journal of Molecular and Cellular Cardiology. 26:1587-1592 |
| ISSN: | 0022-2828 |
| DOI: | 10.1006/jmcc.1994.1178 |
| Popis: | Rats were made hypothyroid by adding propylthiouracil (PTU) to their drinking water. Some of the PTU-treated rats were given thyroid hormone injections for 5 days. Both soluble and particulate cAMP-phosphodiesterase activities of adipose and ventricular tissues were increased by 25-60% in hypothyroidism. In left atria, soluble cAMP-phosphodiesterase activity was not significantly altered in hypothyroidism, while total particulate cAMP-phosphodiesterase activity was lowered by 30%. This lowering was due to diminished isoenzyme IV activity, as studied with the isoenzyme-specific inhibitors rolipram and SK&F 94836. In conclusion, the present results show decreased particulate type IV cAMP-phosphodiesterase activity in hypothyroid rat atria. This may explain the increased responsiveness to isoproterenol in hypothyroid atria. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|