Two nucleolar targeting signals present in the N-terminal part of Semliki Forest virus capsid protein
| Autor: | M. R. Michel, Daniel Favre, Erwin Studer |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Nucleolus
viruses Molecular Sequence Data Alphavirus Kidney Semliki Forest virus Cell Line Capsid Virology Chlorocebus aethiops medicine Animals Amino Acid Sequence Bovine serum albumin Peptide sequence Cell Nucleus biology Serum Albumin Bovine General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Semliki forest virus Molecular biology Cell nucleus medicine.anatomical_structure biology.protein Carrier Proteins Cell Nucleolus Nuclear localization sequence |
| Zdroj: | Archives of Virology. 137:149-155 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | Here we show that the capsid (C) protein of Semliki Forest virus (SFV) contains two nucleolar targeting signals (NOS) responsible for the karyophilic properties of this protein. When conjugated to the non-karyophilic carrier protein bovine serum albumin (BSA), the two synthetic nuclear localization sequences (NLS) of the C protein transferred with equal efficiency the carrier protein into the nucleolus of both higher and lower eukaryotic target cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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