Neurological Manifestations of Enterovirus 71 Infection in Children during an Outbreak of Hand, Foot, and Mouth Disease in Western Australia
| Autor: | Stephen J. Davis, Peter C. McMinn, Ivan Stratov, Lakshmi Nagarajan |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Pediatrics Ataxia Cerebellar Ataxia Neurological disorder Myelitis Transverse Antibodies Viral Guillain-Barre Syndrome Transverse myelitis Disease Outbreaks Enterovirus Infections medicine Enterovirus 71 Humans Meningitis Aseptic Child Enterovirus biology business.industry Australia Infant Aseptic meningitis Outbreak medicine.disease biology.organism_classification Magnetic Resonance Imaging Surgery Infectious Diseases Child Preschool Acute Disease Female Nervous System Diseases medicine.symptom Hand Foot and Mouth Disease business Myoclonus Meningitis Paraneoplastic Syndromes Nervous System |
| Zdroj: | Clinical Infectious Diseases. 32:236-242 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Enterovirus 71 (EV71) causes epidemics of hand, foot, and mouth disease associated with neurological complications in young children. We report an outbreak of EV71-associated neurological disease that occurred from February through September 1999 in Perth, Western Australia. Fourteen children with culture-proven, EV71-induced neurological disease were identified. Nine patients (64%) developed severe neurological disease; 4 of these patients developed long-term neurological sequelae. Neurological syndromes included aseptic meningitis, Guillain-Barré syndrome, acute transverse myelitis, acute cerebellar ataxia, opso-myoclonus syndrome, benign intracranial hypertension, and a febrile convulsion. Clinical and magnetic resonance imaging data indicated that immunopathology was a major factor in the pathogenesis of neurological disease in this outbreak. This finding is in contrast to reports of previous EV71 epidemics, in which virus-induced damage to gray matter was the most frequent cause of neurological disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|