SKF 38393 enhances odor detection performance
| Autor: | Judith M. Risser, William Huang, Ritu Bagla, Richard L. Doty, Cheryl Pfeiffer, Cheng Li, Gary M. Brosvic |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Spiperone Partial agonist chemistry.chemical_compound Quinpirole Dopamine receptor D1 Estrus Internal medicine Dopamine receptor D2 medicine Animals Pharmacology SCH-23390 Behavior Animal Dose-Response Relationship Drug Chemistry Antagonist Benzazepines Rats Smell Endocrinology Odor Dopamine Agonists Odorants Conditioning Operant Dopamine Antagonists Female 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Injections Intraperitoneal Psychomotor Performance medicine.drug |
| Zdroj: | Psychopharmacology. 136(1) |
| ISSN: | 0033-3158 |
| Popis: | The purpose of this study was to determine the influence of the D1-selective partial agonist SKF 38393 on the odor detection performance of rats using high precision olfactometry and a go/no-go operant task. Previous studies have found that the D2 receptor partial agonist quinpirole decreases such performance, but the influences of D1 receptor activation are unknown. In experiment 1, such detection performance to the odorant ethyl acetate was enhanced by SKF 38393, relative to saline, in male rats at 7.5 and 10.0 mg/kg i.p. dose levels, but not at the lower doses of 1.0, 2.5, and 5.0 mg/kg. In experiment 2, this enhancement was replicated at the 7.5 and 10.0 mg/kg doses and was shown to occur at the 12.5 mg/kg dose as well. In experiment 3, similar enhancement was shown for the odorant eugenol in female rats at the 7.5, 10.0 and 12.5 mg/kg doses, suggesting this effect is neither sex-specific nor confined to the odorant ethyl acetate. In experiment 4, a 0.025 mg/kg dose of the D1 receptor antagonist SCH 23390 depressed the enhancement produced to ethyl acetate by 7.5 mg/kg SKF 38393 to control levels. Overall, these data demonstrate that, in contrast to quinpirole, SKF 38393 improves odor detection performance in the rat and that this phenomenon can be attenuated by the D1 receptor blocker SCH 23390. |
| Databáze: | OpenAIRE |
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