Excretion of Urinary N-C14-Methyl Morphine and Pulmonary C14O2 in the Monkey and Dog after Subcutaneous Injection of the Labelled Drug
| Autor: | L. B. Mellett, L. A. Woods |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
Drug
medicine.medical_specialty Injections Subcutaneous Urinary system media_common.quotation_subject Urine Pharmacology General Biochemistry Genetics and Molecular Biology Excretion Subcutaneous injection Dogs Internal medicine medicine Animals Urinary Tract media_common Morphine Codeine Chemistry Biological Transport Haplorhini Metabolism Carbon Dioxide Body Fluids Endocrinology Total dose medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 106:221-223 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-106-26293 |
| Popis: | The results of urinary excretion and C/sup 14/O/sub 2/ elimination experiments in dogs and monkeys receiving 2.0 mg/kg of N-C/sup 14/-methyl morphine, subcutaneously, were as follows: dogs excreted 13 to 15% of the total dose as free morphine and 48 to 52% as conjugated morphine and about 0.2% as exhaled C/sup 14/O/sub 2/. Monkeys excreted 6 to 14% as free morphine and 55 to 71% as conjugated morphine and about 1% as exhaled C/sup 14/O/sub 2/. (auth) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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