Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome
| Autor: | Aaron C. Anselmo, Jamie Webster, Ana Jaklenec, Robert Langer, Kevin J. McHugh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Materials science Swine Drug Compounding 02 engineering and technology Article Bacterial Adhesion Microbiology law.invention Bile Acids and Salts 03 medical and health sciences Probiotic Intestinal mucosa law Animals Humans General Materials Science Microbiome Intestinal Mucosa Drug compounding Gastrointestinal tract Bacillus coagulans Mechanical Engineering Probiotics Gastrointestinal Microbiome 021001 nanoscience & nanotechnology Encapsulation (networking) Intestines 030104 developmental biology Mechanics of Materials 0210 nano-technology |
| Zdroj: | PMC |
| Popis: | Recent discoveries in biology and microbiology have highlighted the importance of the gastrointestinal (GI) microbiome in regulating human health and disease. Thus, the delivery of probiotics to influence and modulate microbiome compositions can potentially impact the treatment of a number of human diseases. Unfortunately, biological challenges encountered during oral delivery have limited the translation of many probiotic-delivering technologies. Here, we report a layer-by-layer (LbL) method for the encapsulation of probiotics to directly address these challenges by protecting probiotics from GI tract insults while facilitating both mucoadhesion and direct growth on intestinal surfaces. |
| Databáze: | OpenAIRE |
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