Once-daily ceftriaxone therapy for serious bacterial infections in children
Autor: | T. A. Rakusan, Blaise L. Congeni, Q. T. Box, Tasnee Chonmaitree |
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Rok vydání: | 1985 |
Předmět: |
Drug
Cefotaxime Adolescent medicine.drug_class media_common.quotation_subject medicine.medical_treatment Antibiotics Microbial Sensitivity Tests medicine.disease_cause medicine Humans Pharmacology (medical) Child media_common Antibacterial agent Pharmacology Chemotherapy business.industry Ceftriaxone Infant Newborn Infant Bacterial Infections Kinetics Infectious Diseases Staphylococcus aureus Child Preschool Anesthesia Drug Evaluation Once daily business Research Article medicine.drug |
Zdroj: | Antimicrobial Agents and Chemotherapy. 27:181-183 |
ISSN: | 1098-6596 0066-4804 |
Popis: | Ceftriaxone administered as a single daily dose of 50 mg/kg was evaluated in the treatment of 35 children with a variety of nonmeningitic bacterial infections. In two of the patients, the drug was discontinued before the response to the drug could be evaluated. All of the remaining patients had a satisfactory response. In 22 of the patients, plasma was available for the determination of ceftriaxone levels 1 h after a dose and immediately before the next dose. All but one of these patients had trough ceftriaxone levels which exceeded the MIC of the infecting organism, although marginally so for Staphylococcus aureus. Ceftriaxone appears to be safe and effective in the treatment of a variety of bacterial pathogens in children when administered at a single daily dose of 50 mg/kg. This drug may be especially useful in those patients in whom outpatient antibiotic therapy is contemplated or in whom maintenance of intravenous access is difficult. |
Databáze: | OpenAIRE |
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