Higher-Than-Conventional Subcutaneous Regular Insulin Doses Following Diabetic Ketoacidosis in Children and Adolescents
| Autor: | Korcan Demir, Behzat Özkan, Özlem Nalbantoğlu, Selma Tunc, Çiğdem Ecevit, Aysel Öztürk, Özlem Bağ |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Diabetic ketoacidosis Adolescent Endocrinology Diabetes and Metabolism Initial dose Injections Subcutaneous Hypoglycemia initial doses Gastroenterology Diabetic Ketoacidosis Endocrinology children Risk Factors Internal medicine regular insulin medicine Humans Hypoglycemic Agents Insulin Child Glycemic Dose-Response Relationship Drug business.industry Insulin dosage Infant medicine.disease Subcutaneous insulin Hospitalization Diabetes Mellitus Type 1 Child Preschool Pediatrics Perinatology and Child Health Regular insulin Original Article Female business type 1 diabetes mellitus |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5735 1308-5727 |
| Popis: | Objective: To evaluate the effect of initial insulin dosage on glycemic control in the first 48 hours of subcutaneous regular insulin therapy after resolution of diabetic ketoacidosis (DKA). Methods: Records of patients with DKA hospitalized in the past 3 years [n=76, median age=10.0 (6.0-12.0) years, Male/Female: 44/32] were reviewed. The patients were designated into two groups according to distribution of starting doses of subcutaneous insulin. Group 1 (n=28) received a median dose of 1.45 U/kg/day (1.41-1.5) and group 2 (n=48) a median dose of 0.96 U/kg/day (0.89-1). Clinical and laboratory data were analyzed. Results: Median, minimum, and maximum blood glucose levels of Group 1 in the first 48 hours of treatment were significantly lower than that of Group 2 [213 (171-242) vs. 255 (222-316), p=200 mg/dL were lower (50% vs. 81.3%) compared to Group 2 (p=0.001 and p |
| Databáze: | OpenAIRE |
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