Does carbamazepine-epoxide conjugate with glutathione? On an existing but almost forgotten possibility
| Autor: | I Herczeg, J Debreczeni, M P Kalapos, K Széll, S Olajos |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cystinuria
medicine.medical_treatment Epoxide Carbamazepine Plasma levels Glutathione Child Behavior Disorders Pharmacology chemistry.chemical_compound Therapeutic index Anticonvulsant chemistry Biochemistry medicine Epoxy Compounds Humans Pharmacology (medical) Anticonvulsants Female Child medicine.drug Carbamazepine epoxide Conjugate |
| Zdroj: | Drug metabolism and drug interactions. 16(3) |
| ISSN: | 0792-5077 |
| Popis: | The anticonvulsant carbamazepine is widely used to treat affective disorders and behavioural disorders in non-epileptic children. We report an elevated plasma level of carbamazepine-10,11-epoxide in a cystinuric child after daily medication with 300 mg carbamazepine while the serum level of carbamazepine was in the therapeutic range. The concentrations of carbamazepine and its epoxide derivative were determined by HPLC. The formation of a glutathione conjugate of carbamazepine-10,11-epoxide is raised as a hypothesis. |
| Databáze: | OpenAIRE |
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