Cochliomycin G, a 14-membered resorcylic acid lactone from a marine-derived fungus Cochliobolus lunatus
| Autor: | Wei-Feng Xu, Yue-Xuan Qi, Chang-Lun Shao, Chang-Yun Wang, Xiao-Jia Xue, Na-Na Wu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Stereochemistry Organic Chemistry Plant Science Fungus biology.organism_classification Cochliobolus lunatus 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry Lactone |
| DOI: | 10.6084/m9.figshare.8427578 |
| Popis: | Cochliomycin G (1), a new 14-membered resorcylic acid lactone, together with six known analogues (2−7), was isolated from the culture broth of a marine-derived fungus Cochliobolus lunatus. The planar structure of 1 was established by extensive NMR spectroscopy, and the absolute configuration was elucidated by the combination of empirical rules, CD data, and 13C chemical shift calculations. Compound 1 exhibited potent antifouling activity against Chlorella vulgaris, Chaetoceros socialis, and Navicula exigua, with EC50 values of 1.09, 0.92, and 0.61 μg/mL, respectively. |
| Databáze: | OpenAIRE |
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