Bisphosphonate-induced osteonecrosis of the ear canal: our experience and a review of the literature
| Autor: | L McCadden, C G Leonard, W J Primrose |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Osteoporosis Esophageal Diseases 03 medical and health sciences 0302 clinical medicine Otology otorhinolaryngologic diseases medicine Humans Ear canal 030223 otorhinolaryngology Aged Aged 80 and over Bisphosphonate-associated osteonecrosis of the jaw Alendronate Bone Density Conservation Agents Diphosphonates business.industry Alendronic acid General Medicine Bisphosphonate medicine.disease Surgery medicine.anatomical_structure Debridement Otorhinolaryngology 030220 oncology & carcinogenesis Bisphosphonate-Associated Osteonecrosis of the Jaw Female business Osteonecrosis of the jaw Complication Ear Canal medicine.drug |
| Zdroj: | The Journal of Laryngology & Otology. 132:372-374 |
| ISSN: | 1748-5460 0022-2151 |
| DOI: | 10.1017/s0022215118000324 |
| Popis: | Background:Oesophageal disorders and osteonecrosis of the jaw are recognised complications of the commonly prescribed medication bisphosphonate. Despite these diagnoses being seen comparatively frequently within the ENT clinic, osteonecrosis of the external ear is a less well reported complication.Methods:The current literature is reviewed and our experience with six cases of bisphosphonate-related ear canal osteonecrosis is presented.Results:Six cases were identified as suffering from ear canal osteonecrosis as a result of bisphosphonate treatment. One of our cases suffered bilateral ear canal osteonecrosis after only 20 months of oral alendronic acid treatment. Management ranged from bisphosphonate cessation and topical treatment, to surgical debridement in the operating theatre.Conclusion:Bisphosphonate-related ear canal osteonecrosis is undoubtedly under-diagnosed. For such a commonly prescribed medication, the risks and side effects of bisphosphonate should be better known and long-term treatment should be avoided if possible. |
| Databáze: | OpenAIRE |
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