High-dose thoracic radiation therapy for non-small cell lung cancer: a novel grading scale of radiation-induced lung injury for symptomatic radiation pneumonitis

Autor: Zsuzsanna Takacs-Szabó, Panagiotis Maidas, Sahar Sulaiman Al-Saadi, Jens Brøndum Frøkjær, Martin Bøgsted, Oluf Dimitri Røe, Ursula Falkmer, Martin Skovmos Nielsen, Tine McCulloch, Jacek Pawlowski, Weronika Maria Szejniuk
Rok vydání: 2021
Předmět:
Male
Organs at Risk
Radiation-related pulmonary toxicity
Lung Neoplasms
medicine.medical_treatment
R895-920
Gastroenterology
030218 nuclear medicine & medical imaging
Medical physics. Medical radiology. Nuclear medicine
0302 clinical medicine
Carcinoma
Non-Small-Cell Lung
Image Processing
Computer-Assisted
Medicine
Lung volumes
Prospective Studies
RC254-282
Observer Variation
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Radiotherapy Dosage
Common Terminology Criteria for Adverse Events
Lung Injury
Middle Aged
Prognosis
Non-small cell lung cancer radiation therapy
Oncology
Radiation-induced lung injury
030220 oncology & carcinogenesis
Female
Radiation pneumonitis
Adult
Radiation therapy toxicity
medicine.medical_specialty
Lung injury
03 medical and health sciences
Internal medicine
Humans
Radiology
Nuclear Medicine and imaging
Radiometry
Lung cancer
Grading (tumors)
Aged
Radiological radiation-induced lung injury scale
business.industry
Research
fungi
medicine.disease
Radiation therapy
Radiotherapy
Intensity-Modulated
sense organs
business
Complication
Zdroj: Radiation Oncology, Vol 16, Iss 1, Pp 1-11 (2021)
Radiation Oncology (London, England)
Szejniuk, W M, Nielsen, M S, Takács-Szabó, Z, Pawlowski, J, Al-Saadi, S S, Maidas, P, Bøgsted, M, McCulloch, T, Frøkjær, J B, Falkmer, U G & Røe, O D 2021, ' High-dose thoracic radiation therapy for non-small cell lung cancer : a novel grading scale of radiation-induced lung injury for symptomatic radiation pneumonitis ', Radiation Oncology, vol. 16, no. 1, 131 . https://doi.org/10.1186/s13014-021-01857-8
Radiation Oncology
ISSN: 1748-717X
DOI: 10.1186/s13014-021-01857-8
Popis: Background Symptomatic radiation pneumonitis (RP) may be a serious complication after thoracic radiation therapy (RT) for non-small cell lung cancer (NSCLC). This prospective observational study sought to evaluate the utility of a novel radiation-induced lung injury (RILI) grading scale (RGS) for the prediction of RP. Materials and methods Data of 41 patients with NSCLC treated with thoracic RT of 60–66 Gy were analysed. CT scans were scheduled before RT, one month post-RT, and every three months thereafter for one year. Symptomatic RP was defined as Common Terminology Criteria for Adverse Events grade ≥ 2. RGS grading ranged from 0 to 3. The inter-observer variability of the RGS was assessed by four senior radiologists. CT scans performed 28 ± 10 days after RT were used to analyse the predictive value of the RGS. The change in the RGS severity was correlated to dosimetric parameters. Results The CT obtained one month post-RT showed RILI in 36 (88%) of patients (RGS grade 0 [5 patients], 1 [25 patients], 2 [6 patients], and 3 [5 patients]). The inter-observer agreement of the RGS grading was high (Kendall’s W coefficient of concordance = 0.80, p p p Conclusions The RGS is a simple radiologic tool associated with symptomatic RP. A validation study is warranted.
Databáze: OpenAIRE
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