The evolution of CT diagnosed papillae tip microcalcifications: can we predict the development of stones?
| Autor: | Javier Sánchez, Ricardo Alvarez-Vijande, Agustín Franco, A. Ciudin, Vlad Constantin, Antonio Collado-Belvis, M.G. Diaconu, Rafael Salvador, Maria Pilar Luque, Carlos Nicolau, Antonio Alcaraz |
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| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Càlculs renals Time Factors Urology Radiography Population Urinary Bladder Tomografia computada per emissió de fotó simple Anamnesi Kidney Risk Assessment Genitourinary organs diseases Kidney Calculi Ureter Hounsfield scale medicine Humans Clinical significance education Retrospective Studies Medical history taking education.field_of_study Kidney Medulla business.industry Ultrasound Calcinosis Retrospective cohort study Middle Aged Single-photon emission computed tomography medicine.anatomical_structure Estudi de casos Kidney calculi Female Radiology Tomography Case studies business Tomography X-Ray Computed Malalties de l'aparell genitourinari |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| Popis: | OBJECTIVES: To determine the incidence of computed tomography (CT) identifiable Randall plaques in a CT explored population; to determine the clinical relevance of this radiological finding by a 7-year follow-up; to determine a cut point to identify a population with high risk of developing calcium stone disease (SD). MATERIALS AND METHODS: Retrospective study of all patients explored by abdominal CT in our center between January and March 2005. INCLUSION CRITERIA: age 30-60 years and no SD. Papillae attenuation was measured on nonenhanced CT in Hounsfield units (HU) and the mean of all papillae was calculated. Patients were re-evaluated after 7 years to identify calcium stone formers. Anamnesis and already available CT, ultrasound, kidney, ureter, and bladder radiograph (KUB) or intravenous urography (IVU) images performed as part of their follow-up were used. In patients with no follow-up, ultrasound and KUB were to be performed. Pearson correlation, Student t-test, and the receiver operator curve were used for statistical analysis. RESULTS: A total of 362 patients fulfilled the inclusion criteria and were analyzed; 12 developed calcium SD after 7 years. A significant difference was encountered between the papillae attenuation of stone formers (SF) versus non-SF (47.2HU vs. 35.5HU, p=0.001). There was good correlation between papillae attenuation and the possibility of developing SD (R=0.87). An optimal cut point of 43HU with a sensitivity of 81% and specificity of 97%, area under the curve 0.91, separated SF and non-SF. CONCLUSION: Patients with high papillae density have a higher risk of developing SD. A cut point of 43HU could accurately be used to identify a high-risk population. |
| Databáze: | OpenAIRE |
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