Disrupted functional connectivity in primary progressive apraxia of speech
| Autor: | Nirubol Tosakulwong, Edythe A. Strand, David T.W. Jones, Mary M. Machulda, Hugo Botha, Heather M. Clark, Keith A. Josephs, Clifford R. Jack, David S. Knopman, Ronald C. Petersen, Jennifer L. Whitwell, Rene L. Utianski, Joseph R. Duffy |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Audiology Apraxia MMSE Mini-Mental State Examination Intrinsic connectivity networks lcsh:RC346-429 Functional connectivity 0302 clinical medicine Degenerative disease Gyrus AES Articulatory Error Score Motor speech disorders TOJ Temporal-Occipital Junction TT Token Test Language Aged 80 and over medicine.diagnostic_test Supplementary motor area 05 social sciences ICN Intrinsic Connectivity Network WAB Western Aphasia Battery Brain Regular Article NPI-S Neuropsychiatric Inventory – Severity SMA Supplementary Motor Area PFC Prefrontal Cortex Middle Aged Magnetic Resonance Imaging AOS Apraxia Of Speech UPDRS Unified Parkinson Disease Rating Scale medicine.anatomical_structure Neurology BNT Boston Naming Test lcsh:R858-859.7 Female Psychology medicine.medical_specialty Apraxias Cognitive Neuroscience FBI Frontal Behavioral Inventory PCC Posterior Cingulate Cortex lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology 03 medical and health sciences AQ Aphasia Quotient ASRS Apraxia of Speech Severity Rating Scale Apraxia of speech medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Aged Working memory medicine.disease FAB Frontal Assessment Battery PPA Primary Progressive Aphasia NVOA Nonverbal Oral Apraxia Posterior cingulate agPPA Agrammatic/Nonfluent PPA Neurology (clinical) Nerve Net Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 18, Iss, Pp 617-629 (2018) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Apraxia of speech is a motor speech disorder thought to result from impaired planning or programming of articulatory movements. It can be the initial or only manifestation of a degenerative disease, termed primary progressive apraxia of speech (PPAOS). The aim of this study was to use task-free functional magnetic resonance imaging (fMRI) to assess large-scale brain network pathophysiology in PPAOS. Twenty-two PPAOS participants were identified from a prospective cohort of degenerative speech and language disorders patients. All participants had a comprehensive, standardized evaluation including an evaluation by a speech-language pathologist, examination by a behavioral neurologist and a multimodal imaging protocol which included a task-free fMRI sequence. PPAOS participants were age and sex matched to amyloid-negative, cognitively normal participants with a 1:2 ratio. We chose a set of hypothesis driven, predefined intrinsic connectivity networks (ICNs) from a large, out of sample independent component analysis and then used them to initialize a spatiotemporal dual regression to estimate participant level connectivity within these ICNs. Specifically, we evaluated connectivity within the speech and language, face and hand sensorimotor, left working memory, salience, superior parietal, supramarginal, insular and deep gray ICNs in a multivariate manner. The spatial maps for each ICN were then compared between PPAOS and control participants. We used clinical measures of apraxia of speech severity to assess for clinical-connectivity correlations for regions found to differ between PPAOS and control participants. Compared to controls, PPAOS participants had reduced connectivity of the right supplementary motor area and left posterior temporal gyrus to the rest of the speech and language ICN. The connectivity of the right supplementary motor area correlated negatively with an articulatory error score. PPAOS participants also had reduced connectivity of the left supplementary motor area to the face sensorimotor ICN, between the left lateral prefrontal cortex and the salience ICN and between the left temporal-occipital junction and the left working memory ICN. The latter connectivity correlated with the apraxia of speech severity rating scale, although the finding did not survive correction for multiple comparisons. Increased connectivity was noted in PPAOS participants between the dorsal posterior cingulate and the left working memory ICN. Our results support the importance of the supplementary motor area in the pathophysiology of PPAOS, which appears to be disconnected from speech and language regions. Supplementary motor area connectivity may serve as a biomarker of degenerative apraxia of speech severity. Highlights • This is the first study of the network level connectivity changes underlying PPAOS. • We found changes in speech and language, face, working memory and salience networks. • Right SMA connectivity to speech and language areas correlated with AOS severity. |
| Databáze: | OpenAIRE |
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