A cross-cultural study: anti-inflammatory activity of Australian and Chinese plants
| Autor: | Gregory J. Leach, Stephen P Myers, Rachel W. Li, David N Leach, G. David Lin |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
China
medicine.drug_class Anti-Inflammatory Agents Traditional Chinese medicine Pharmacognosy Anti-inflammatory law.invention law Drug Discovery medicine Cyclooxygenase Inhibitors Medicinal plants Pharmacology Acacia adsurgens Plants Medicinal Ethanol biology Traditional medicine Plant Extracts business.industry Australia Moraceae biology.organism_classification Isoenzymes Prostaglandin-Endoperoxide Synthases visual_art Cyclooxygenase 1 visual_art.visual_art_medium Bark Phytotherapy business Drugs Chinese Herbal |
| Zdroj: | Journal of Ethnopharmacology. 85:25-32 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/s0378-8741(02)00336-7 |
| Popis: | In this study, in vitro inhibitory effects of 33 ethanol extracts obtained from 24 plant species (representing 11 different families) on cyclooxygenase-1 (COX-1) were evaluated. The plant materials selected for this study have been used in aboriginal medicine in Australia and traditional medicine in China for the treatment of various diseases that are considered as inflammation in nature, e.g. asthma, arthritis, rheumatism, fever, edema, infections, snakebite and related inflammatory diseases. All of the selected plants, with one exception, showed inhibitory activity against COX-1, which supports their traditional uses. The most potent COX-1 inhibition were observed from the extracts of Acacia ancistrocarpa leaves (IC 50 =23 μg/ml). Ficus racemosa bark, Clematis pickeringii stem, Acacia adsurgens leaves, Tinospora smilacina stem and Morinda citrifolia fruit powder exhibited inhibition of COX-1 with the IC 50 of 100, 141, 144, 158 and 163 μg/ml, respectively. Aspirin and indomethacin used as the reference COX-1 inhibitors in this study inhibited COX-1 with IC 50 of 241 and 1.2 μg/ml, respectively. The findings of this study may explain at least in part why these plants have been traditionally used for the treatment of inflammatory conditions in Australian aboriginal medicine and traditional Chinese medicine. |
| Databáze: | OpenAIRE |
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