Simultaneous chiral resolution of two racemic compounds by preferential cocrystallization
| Autor: | Joop H. ter Horst, Chloé Matheys, Tom Leyssens, Laurent Collard, Maxime D. Charpentier, Fuli Zhou, Oleksii Shemchuk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Etiracetam
010405 organic chemistry General Medicine General Chemistry 010402 general chemistry Mandelic acid 01 natural sciences Combinatorial chemistry Catalysis Chiral resolution 0104 chemical sciences law.invention chemistry.chemical_compound chemistry law medicine QD Enantiomer Crystallization medicine.drug |
| ISSN: | 1433-7851 |
| Popis: | We tap into an unexplored area of preferential crystallization, being the first to develop simultaneous chiral resolution of two racemic compounds by preferential cocrystallization.We highlight how the two racemic compounds RS-mandelic acid (MAN) and RS-etiracetam (ETI) can be combined together as enantiospecific R-MAN:R-ETI and S-Man:S-ETI cocrystals forming a stable conglomerate system and subsequently develop a cyclic preferential crystallization allowing to simultaneous resolve both compounds. The developed process leads to excellent enantiopurity both for etiracetam (ee>98%) and mandelic acid (ee~95%) enantiomers |
| Databáze: | OpenAIRE |
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