Antibodies against Gag are diagnostic markers for feline foamy virus infections while Env and Bet reactivity is undetectable in a substantial fraction of infected cats
| Autor: | Silke Bachmann, Hans Lutz, Johannes Schröder, Martin Löchelt, Michael Pawlita, Peter Sehr, Fabian Romen |
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| Rok vydání: | 2006 |
| Předmět: |
viruses
Retroviridae Proteins Feline foamy virus Gene Products gag Enzyme-Linked Immunosorbent Assay Antibodies Viral Cat Diseases Antigen Virology Diagnostic marker Animals CATS biology Transmission (medicine) Gene Products env Clinical disease Genes gag Recombinant Proteins Humoral immunity Cats biology.protein Spumavirus ELISA Foamy virus Antibody Biomarkers Retroviridae Infections |
| Zdroj: | Virology. 345:502-508 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2005.10.022 |
| Popis: | Spumaretroviruses or foamy viruses constitute a distinct subfamily of retroviruses. The biology of foamy viruses within the authentic host, their mode of transmission, and disease potential in the authentic host or after zoonotic transmission into human or other species are almost unknown. Using feline foamy virus (FFV) as model system, we established modular enzyme-linked immunosorbent assays (ELISA) suited to determine feline IgG and IgM antibody responses against structural and non-structural FFV proteins. We validated the ELISAs with standard reference sera. In 99 cats admitted to a Swiss veterinary hospital, overall FFV Gag antibody prevalence was 36%, reactivity against Env and the non-structural protein Bet each was about 25%, and 19% of the sera were directed against all three FFV antigens. With one exception, all Bet- and/or Env-positive sera were also positive for Gag. In this small epidemiological pilot study, FFV antibodies were not significantly associated with clinical disease. |
| Databáze: | OpenAIRE |
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