Scrub typhus associated acute kidney injury—a study from a tertiary care hospital from western Himalayan state of India

Autor:	Surinder Thakur, Anupam Parashar, Ashok Sharma, Anil Kanga, Kaushal Ss, Dalip Gupta, Santosh Kumar Dheer, Sanjay Vikrant
Rok vydání:	2013
Předmět:	Adult Male medicine.medical_specialty ARDS Adolescent India Scrub typhus Critical Care and Intensive Care Medicine Tertiary Care Centers Young Adult Internal medicine medicine Humans Hypoalbuminemia Child Intensive care medicine Aged Retrospective Studies business.industry Septic shock Acute kidney injury General Medicine Acute Kidney Injury Middle Aged medicine.disease Hypokalemia Scrub Typhus Nephrology Female Hypernatremia medicine.symptom business Hyponatremia
Zdroj:	Renal Failure. 35:1338-1343
ISSN:	1525-6049 0886-022X
Popis:	To report the clinical profile of acute kidney injury (AKI) associated with scrub typhus.Retrospective study of hospitalized patients of acute febrile illness who were diagnosed scrub typhus and had AKI.174 (35%) patients (75.9% female), mean age (41.4 ± 15.9 years) were studied. The laboratory abnormalities were: anemia (63.2%), leukocytosis (44.3%), thrombocytopenia (61.5%), hyponatremia (35.6%), hypernatremia (2.9%), and hypokalemia (12.1%), hyperkalemia (11.5%), hypoalbuminemia (56.9%), hepatic dysfunction (70%) and metabolic acidosis (28.7%). The complications of hypotension (5.7%), septic shock (3.4%), pneumonia (10.9%), acute respiratory distress syndrome (ARDS) (11.5%), meningoencephalitis (6.9%), encephalopathy (5.2%), gastrointestinal bleed (1.3%), myocarditis (3.4%), disseminated intravascular coagulation (2.9%) and multi organ failure (MOF) (10.3%) developed during course of hospitalization in these patients. Twenty-five (14.4%) patients required intensive care support (ICU) support and seven (4%) patients were dialyzed. 146 (83.9%) patients survived. Twenty-eight (16.1%) patients died. There was a significant difference in the age, various hematologicalbiochemical abnormalities, complications and need for ICU support in the non-survival group as compared the survival group.This study shows that AKI in scrub typhus is common and a severe disease. Age, a shorter hospital stay, severities of leukocytosis, thrombocytopenia, azotemia, hypoalbuminemia, hepatic dysfunction and the complications of ARDS, encephalopathy, MOF and need for ICU support are the factors associated with mortality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed3211727a24fa71872a334e8a213d8 https://doi.org/10.3109/0886022x.2013.828257 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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