Synthesis and biological evaluation of copper (II) complexes of sterically hindered o-aminophenol derivatives as antimicrobial agents
| Autor: | G. K. Glushonok, T.V. Koval’chuk, R.A. Zheldakova, G. A. Ksendzova, A.A. Chernyavskaya, Oleg I. Shadyro, G. I. Polozov, N.P. Osipovich, N.V. Loginova, Victor L. Sorokin |
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| Rok vydání: | 2006 |
| Předmět: |
Steric effects
Denticity Stereochemistry Clinical Biochemistry Molecular Conformation Pharmaceutical Science chemistry.chemical_element Microbial Sensitivity Tests In Vitro Techniques Aminophenols Biochemistry Medicinal chemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Deprotonation Anti-Infective Agents Drug Discovery Organometallic Compounds Phenol Phenols Molecular Biology Molecular Structure Ligand Organic Chemistry Copper chemistry Molecular Medicine |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 16:5403-5407 |
| ISSN: | 0960-894X |
| Popis: | Cu(II) complexes with 4,6-di( tert -butyl)-2-aminophenol ( I ) and 2-anilino-4,6-di( tert -butyl)phenol ( II ) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, UV–vis, ESR, and conductance measurements. The compounds I and II can coordinate in their singly deprotonated forms and behave as bidentate O,N-coordinated ligands; their CuL 2 complexes are characterized by CuN 2 O 2 coordination modes and square planar geometry. In vitro antimicrobial screening against Gram-positive and Gram-negative bacteria, yeasts, and moulds indicated that the compound I and its Cu(II) complex were more active than Questiomycin B, the compound II , and its Cu(II) complex. |
| Databáze: | OpenAIRE |
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