Chronic inflammation in polycystic ovary syndrome: A case–control study using multiple markers
| Autor: | Basudev Bhattacharya, Sujoy Ghosh, Subhadip Choudhuri, Rana Bhattacharjee, Soumik Goswami, Ajitesh Roy, Subhankar Chowdhury, Satinath Mukhopadhyay |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
QH471-489 030209 endocrinology & metabolism Inflammation polycystic ovary syndrome inflammation c-reactive protein interleukin-6 tumor necrosis factor microparticles 03 medical and health sciences 0302 clinical medicine Insulin resistance Waist–hip ratio Diabetes mellitus Internal medicine Medicine 030219 obstetrics & reproductive medicine biology business.industry Reproduction Hyperandrogenism C-reactive protein Case-control study nutritional and metabolic diseases Obstetrics and Gynecology Gynecology and obstetrics medicine.disease Polycystic ovary Endocrinology Reproductive Medicine RG1-991 biology.protein medicine.symptom business |
| Zdroj: | International Journal of Reproductive BioMedicine, Vol 19, Pp 313-320 (2021) |
| ISSN: | 2476-3772 2476-4108 |
| DOI: | 10.18502/ijrm.v19i4.9057 |
| Popis: | Background: Polycystic ovary syndrome (PCOS) is associated with insulin resistance and elevated risk of cardiovascular disease and diabetes. Chronic inflammation has been observed in PCOS in several studies but there is also opposing evidence and a dearth of research in Indians. Objective: To estimate chronic inflammation in PCOS and find its relationship with appropriate anthropometric and biochemical parameters. Materials and Methods: Chronic inflammation was assessed in 30 women with PCOS (Group A) and 30 healthy controls (Group B) with highly sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), tumour necrosis factor alpha (TNFα), and platelet microparticles (PMP). In group A, the relationship of chronic inflammation with insulin resistance, waist hip ratio (WHR) serum testosterone, and serum glutamate pyruvate transaminase (SGPT) were examined. Results: In group A, the hsCRP, TNFα, and PMP were significantly elevated compared to group B. However, IL-6 level was similar between the groups. In group A, PMP showed a significant positive correlation with waist-hip ratio and serum testosterone. IL-6 showed a significant positive correlation with insulin sensitivity and significant negative correlation with insulin resistance and serum glutamate pyruvate transaminase. Conclusion: PCOS is associated with chronic inflammation and PMP correlates positively with central adiposity and biochemical hyperandrogenism in women with PCOS. Key words: Polycystic ovary syndrome, Inflammation, C-reactive protein, Interleukin-6, Tumor necrosis factor, Microparticles. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|