Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean
| Autor: | Kunishige Kataoka, Satoshi Yamashita, Kohei Takeshita, Riki Imaizumi, Hiroki Kubo, Naoki Sakai, Toru Nakayama, Toshiyuki Waki, Shun Nakata, Masaki Yamamoto, Seiji Takahashi, Ryo Mameda |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Chalcone synthase endocrine system 0303 health sciences biology 030302 biochemistry & molecular biology Flavonoid Crystal structure Biochemistry Isozyme 03 medical and health sciences Enzyme chemistry Isoflavonoid Structural Biology Isoflavonoid biosynthesis biology.protein Metabolon Molecular Biology 030304 developmental biology |
| Zdroj: | ProteinsREFERENCES. |
| ISSN: | 1097-0134 |
| Popis: | Isoflavonoid is one of the groups of flavonoids that play pivotal roles in the survival of land plants. Chalcone synthase (CHS), the first enzyme of the isoflavonoid biosynthetic pathway, catalyzes the formation of a common isoflavonoid precursor. We have previously reported that an isozyme of soybean CHS (termed GmCHS1) is a key component of the isoflavonoid metabolon, a protein complex to enhance efficiency of isoflavonoid production. Here, we determined the crystal structure of GmCHS1 as a first step of understanding the metabolon structure, as well as to better understand the catalytic mechanism of GmCHS1. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text