Perioperative neurocognitive dysfunction: thinking from the gut?
| Autor: | Chun Yang, Enshi Yan, Xiaolin Xu, Yimin Hu, Gaofeng Zhan, Cunming Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
brain-gut axis
Aging medicine.medical_specialty Neurocognitive Disorders Review Gut flora digestive system postoperative delirium Cognition Postoperative Complications Neurocognitive Dysfunction Risk Factors medicine Animals Humans Postoperative delirium Cognitive decline Perioperative Period Intensive care medicine gut microbiota biology business.industry postoperative cognitive dysfunction Probiotics perioperative neurocognitive dysfunction Age Factors Brain Cell Biology Perioperative biology.organism_classification medicine.disease Gastrointestinal Microbiome Intestines Host-Pathogen Interactions Dysbiosis business Postoperative cognitive dysfunction Neurocognitive |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | With the aging of the world population, and improvements in medical and health technologies, there are increasing numbers of elderly patients undergoing anaesthesia and surgery. Perioperative neurocognitive dysfunction has gradually attracted increasing attention from academics. Very recently, 6 well-known journals jointly recommended that the term perioperative neurocognitive dysfunction (defined according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition) should be adopted to improve the quality and consistency of academic communications. Perioperative neurocognitive dysfunction currently includes preoperatively diagnosed cognitive decline, postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction. Increasing evidence shows that the gut microbiota plays a pivotal role in neuropsychiatric diseases, and in central nervous system functions via the microbiota-gut-brain axis. We recently reported that abnormalities in the composition of the gut microbiota might underlie the mechanisms of postoperative cognitive dysfunction and postoperative delirium, suggesting a critical role for the gut microbiota in perioperative neurocognitive dysfunction. This article therefore reviewed recent findings on the linkage between the gut microbiota and the underlying mechanisms of perioperative neurocognitive dysfunction. |
| Databáze: | OpenAIRE |
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