Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases
| Autor: | Judith F. Ashouri, Sidhartha R. Sinha, Yan Jiang, Priyanka Jadhav, Cosima Layton, Karolin Jarr |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Crohn’s disease Male rheumatoid arthritis Curcumin lcsh:TX341-641 Disease Review Bioinformatics Inflammatory bowel disease Autoimmune Diseases Arthritis Rheumatoid 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine UC Fish Oils inflammatory bowel disease Psoriasis Medicine Humans Microbiome Vitamin D ulcerative colitis Crohn's disease Nutrition and Dietetics business.industry psoriasis medicine.disease Inflammatory Bowel Diseases Ulcerative colitis CD 030104 developmental biology probiotics inflammation Rheumatoid arthritis Dietary Supplements 030211 gastroenterology & hepatology Female business prebiotics lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 12, Iss 2156, p 2156 (2020) Nutrients |
| ISSN: | 2072-6643 |
| Popis: | The microbiome is an important contributor to a variety of fundamental aspects of human health, including host metabolism, infection, and the immune response. Gut dysbiosis has been identified as a contributor to the errant immune response in a variety of immune-mediated inflammatory diseases (IMIDs), such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and psoriatic disease (psoriasis and psoriatic arthritis). Given this, probiotics and prebiotics have been investigated as therapeutic options in these disease states. In our review, we highlight the current evidence on prebiotics and probiotics as well as other supplements (such as fish oils, vitamin D, and curcumin) as therapies for IBD. Recommendations, however, regarding the specific use of such supplements in IBD have been lacking, particularly from professional societies, often due to study limitations related to small sample sizes and design heterogeneity. Hence, we additionally examine the literature on the use of prebiotics, probiotics, and other supplements in related IMIDs, namely RA and psoriasis/psoriatic arthritis, as these diseases share many approved therapeutic options with IBD. Based on these combined findings, we offer additional evidence that may help guide clinicians in their treatment of patients with IBD (and other IMIDs) and provide recommendations on potential next steps in therapeutic research in this area. |
| Databáze: | OpenAIRE |
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