Serum calcium levels are associated with novel cardiometabolic risk factors in the population-based CoLaus study
| Autor: | Murielle Bochud, Olivier Bonny, Peter Vollenweider, Fred Paccaud, Vincent Mooser, Idris Guessous, Gérard Waeber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
Epidemiology medicine.medical_treatment lcsh:Medicine 030204 cardiovascular system & hematology medicine.disease_cause Cardiovascular Body Mass Index chemistry.chemical_compound 0302 clinical medicine Endocrinology Switzerland/epidemiology Risk Factors Insulin Clinical Epidemiology lcsh:Science Multidisciplinary Calcium/blood Middle Aged 3. Good health Cardiovascular Diseases Hypertension Medicine Female Public Health Switzerland Adult Cardiovascular Diseases/blood Cardiovascular Diseases/epidemiology Humans Metabolic Diseases/blood Metabolic Diseases/epidemiology Research Article medicine.medical_specialty chemistry.chemical_element 030209 endocrinology & metabolism Calcium Biology 03 medical and health sciences Metabolic Diseases/blood/epidemiology Insulin resistance Metabolic Diseases Internal medicine medicine Cardiovascular Diseases/blood/epidemiology Cardiovascular Disease Epidemiology ddc:613 Diabetic Endocrinology Adiponectin Endocrine Physiology lcsh:R Diabetes Mellitus Type 2 medicine.disease Biomarker Epidemiology chemistry Metabolic Disorders Uric acid lcsh:Q Metabolic syndrome Body mass index Oxidative stress |
| Zdroj: | PLOS ONE, Vol. 6, No 4 (2011) P. e18865 PloS one PLoS ONE PLoS One, vol. 6, no. 4, pp. e18865 PLoS ONE, Vol 6, Iss 4, p e18865 (2011) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Associations of serum calcium levels with the metabolic syndrome and other novel cardio-metabolic risk factors not classically included in the metabolic syndrome, such as those involved in oxidative stress, are largely unexplored. We analyzed the association of albumin-corrected serum calcium levels with conventional and non-conventional cardio-metabolic risk factors in a general adult population. METHODOLOGY/PRINCIPAL FINDINGS: The CoLaus study is a population-based study including Caucasians from Lausanne, Switzerland. The metabolic syndrome was defined using the Adult Treatment Panel III criteria. Non-conventional cardio-metabolic risk factors considered included: fat mass, leptin, LDL particle size, apolipoprotein B, fasting insulin, adiponectin, ultrasensitive CRP, serum uric acid, homocysteine, and gamma-glutamyltransferase. We used adjusted standardized multivariable regression to compare the association of each cardio-metabolic risk factor with albumin-corrected serum calcium. We assessed associations of albumin-corrected serum calcium with the cumulative number of non-conventional cardio-metabolic risk factors. We analyzed 4,231 subjects aged 35 to 75 years. Corrected serum calcium increased with both the number of the metabolic syndrome components and the number of non-conventional cardio-metabolic risk factors, independently of the metabolic syndrome and BMI. Among conventional and non-conventional cardio-metabolic risk factors, the strongest positive associations were found for factors related to oxidative stress (uric acid, homocysteine and gamma-glutamyltransferase). Adiponectin had the strongest negative association with corrected serum calcium. CONCLUSIONS/SIGNIFICANCE: Serum calcium was associated with the metabolic syndrome and with non-conventional cardio-metabolic risk factors independently of the metabolic syndrome. Associations with uric acid, homocysteine and gamma-glutamyltransferase were the strongest. These novel findings suggest that serum calcium levels may be associated with cardiovascular risk via oxidative stress. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|