Effect of contrast dose in the quantification of myocardial extra-cellular volume in adenosine stress/rest perfusion cardiac magnetic resonance examinations

Autor: Loreto García del Barrio, Jesus Pueyo, Pablo Bartolomé, Andreas Greiser, Óscar Fernández González, Meylin Caballeros, Gorka Bastarrika
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Adenosine
Rest
Vasodilator Agents
media_common.quotation_subject
Adenosine stress
Contrast Media
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
03 medical and health sciences
Coronary circulation
0302 clinical medicine
Coronary Circulation
Internal medicine
medicine
Humans
Contrast (vision)
Radiology
Nuclear Medicine and imaging
Prospective Studies
Rest (music)
media_common
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Myocardium
Magnetic resonance imaging
General Medicine
Middle Aged
Magnetic Resonance Imaging
Cardiac Imaging Techniques
Contrast medium
medicine.anatomical_structure
Exercise Test
Cardiology
Female
Myocardial fibrosis
Extracellular Space
Nuclear medicine
business
Perfusion
Zdroj: Acta Radiologica. 58:809-815
ISSN: 1600-0455
0284-1851
Popis: Background Diffuse myocardial fibrosis can be quantified by calculating extra-cellular volume (ECV) from native and post-contrast T1 values using dedicated single bolus contrast medium injection protocols. Purpose To evaluate differences in T1 maps and myocardial ECV measurements in routine stress/rest perfusion cardiovascular magnetic resonance (CMR) examinations after injection of single and double dose of contrast medium. Material and Methods Thirty-seven consecutive patients (30 men; mean age, 62 ± 13 years) underwent clinically indicated adenosine stress/rest perfusion CMR examination to rule out myocardial ischemia following a conventional split-dose contrast medium injection strategy. Native and post-contrast T1 mapping was performed 15 min after the first (0.1 mmol/kg) and second (0.1 mmol/kg) dose of contrast medium using a breath-held Modified Look-Locker Inversion recovery (MOLLI) sequence. Student’s t-test for paired samples, Bland–Altman plots, and concordance-correlation coefficients (CCC) for agreement between T1 and ECV calculations after single and double dose of contrast medium were calculated. Intra- and inter-observer agreement for measurements was also analyzed. Results Myocardial T1 values after single and double dose of contrast medium significantly differed (mean difference of 114.1 ± 19.9 ms, P Conclusion Quantification of myocardial ECV on conventional stress/rest perfusion CMR examination is feasible. T1 maps obtained 15 min after 0.1 mmol/kg of contrast medium provide slightly higher myocardial T1 measurements and ECV values compared with T1 maps obtained after a total dose of 0.2 mmol/kg.
Databáze: OpenAIRE
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