Intraperitoneal Fat through GRP78: A Risk Factor for Endometrial Cancer
| Autor: | Radu Mocan, Maria Rada, Dan Mihu, Costin Berceanu, Carmen Elena Bucuri, Cristian I. Iuhas, Andrei Mihai Măluţan, Răzvan Ciortea |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Article Subject Group ii Gastroenterology Pathology and Forensic Medicine 03 medical and health sciences Peritoneum Risk Factors Internal medicine medicine Humans Risk factor Stage (cooking) Endoplasmic Reticulum Chaperone BiP RC254-282 Heat-Shock Proteins Adiposity Aged QH573-671 business.industry Endometrial cancer Endoplasmic reticulum Ultrasound Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell Biology General Medicine medicine.disease Endometrial Neoplasms 030104 developmental biology Endocrinology medicine.anatomical_structure Linear Models Molecular Medicine Biomarker (medicine) Female business Cytology Research Article |
| Zdroj: | Analytical Cellular Pathology (Amsterdam) Analytical Cellular Pathology, Vol 2016 (2016) |
| ISSN: | 2210-7185 2210-7177 |
| Popis: | Introduction.The identification of biological markers that indicate an increased risk for the development or recurrence of endometrial cancer (EC) in obese women might be useful for decreasing EC mortality and morbidity. Glucose-regulated protein 78 (GRP78) is a major protein of the endoplasmic reticulum expressed in all normal cells. Overexpression of GRP78 has been reported to be a tumoral biomarker. Increased detection of GRP78 is positively correlated with the tumoral stage and prognosis. This study aimed to identify a correlation between intraperitoneal fat, plasma GRP78 levels, and EC.Materials and Methods.Two groups of patients were included in the study: group I, 44 patients diagnosed with EC, and group II, 44 patients without gynecological pathology or inflammatory disorders. Visceral fat was determined by ultrasound and plasma GRP78 levels were measured.Results. Plasma GRP78 levels were significantly higher in patients with EC compared to the control group. Intraperitoneal fat was in a positive linear correlation with the plasma GRP78 level (p<0.0001).Conclusion.The measurement of the GRP78 level associated with the determination of intraperitoneal fat can be a useful predictor for EC. |
| Databáze: | OpenAIRE |
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