Ameliorating effect of selenium on chromium (VI)-induced oxidative damage in the brain of adult rats
| Autor: | Ibtissem Ben Amara, Najiba Zeghal, Tahia Boudawara, Afef Troudi, Nejla Soudani, Hanen Bouaziz |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Antioxidant Physiology medicine.medical_treatment Ascorbic Acid medicine.disease_cause Biochemistry Antioxidants Lipid peroxidation Superoxide dismutase Selenium chemistry.chemical_compound Cerebellum Internal medicine medicine Animals Rats Wistar Cerebrum chemistry.chemical_classification biology Glutathione peroxidase Brain General Medicine Glutathione Malondialdehyde Rats Oxidative Stress Endocrinology chemistry Catalase biology.protein Female Potassium Dichromate Lipid Peroxidation Oxidation-Reduction Oxidative stress |
| Zdroj: | Journal of Physiology and Biochemistry. 68:397-409 |
| ISSN: | 1877-8755 1138-7548 |
| Popis: | Chromium is known for its wide toxic manifestations. This experiment aims to evaluate the effect of selenium against oxidative stress induced by chromium in the cerebrum and cerebellum. Female Wistar rats were randomly divided into four groups of six each: group I served as controls which received the standard diet; group II received drinking water K(2)Cr(2)O(7) alone (700 ppm); group III received both K(2)Cr(2)O(7) and Se (0.5 mg Na(2)SeO(3)/kg of diet); and group IV received Se (0.5 mg/kg of diet) for 3 weeks. The exposure of rats to K(2)Cr(2)O(7) promoted oxidative stress in the cerebrum and cerebellum with an increase in malondialdehyde and a decrease of nonenzymatic antioxidant levels such as glutathione, nonprotein thiol, and vitamin C. An increase of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also observed. Acetylcholinesterase activity was inhibited after treatment with K(2)Cr(2)O(7). Co-administration of Se restored the parameters cited above. The histopathological findings confirmed the biochemical results. |
| Databáze: | OpenAIRE |
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