Human Leukocyte Antigen Class I and Class II Polymorphisms and Serum Cytokine Profiles in Cervical Cancer

Autor: Daniela Frizon Alfieri, Marcia Edilaine Lopes Consolaro, Francieli Delongui, Edna Maria Vissoci Reiche, Roger Haruki Yamakawa, Raquel P. Souza, Larissa Danielle Bahls, Tamires Flauzino, Andre Lp de Abreu, Karina Zanão, Sueli Donizete Borelli, Fabrícia Gimenes
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Adult
Adolescent
medicine.medical_treatment
Human leukocyte antigen
Biology
genes
major histocompatibility complex class II
serum cytokines
Catalysis
Article
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Immune system
HLA Antigens
uterine cervical neoplasms
medicine
Humans
Physical and Theoretical Chemistry
Allele
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
genes
major histocompatibility complex class I
papillomavirus infections
uterine cervical dysplasia
Aged
Cervical cancer
Polymorphism
Genetic
Organic Chemistry
Haplotype
Cancer
Interleukin
General Medicine
Middle Aged
medicine.disease
Computer Science Applications
Neoplasm Proteins
030104 developmental biology
Cytokine
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
Immunology
Cytokines
Female
Zdroj: International Journal of Molecular Sciences; Volume 18; Issue 9; Pages: 1478
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1478 (2017)
International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: 10.3390/ijms18091478
Popis: Only a small proportion of women who are exposed to infection with high-risk human papillomavirus (HR-HPV) progress to persistent infection and develop cervical cancer (CC). The immune response and genetic background of the host may affect the risk of progression from a HR-HPV infection to lesions and cancer. However, to our knowledge, no studies has been conducted to evaluate the relationship between variability of human leukocyte antigens (HLA) genes and serum cytokine expression in this pathology. In the current study, we examined the associations of HLA alleles and haplotypes including Class I (HLA-A, -B and -C) and II (HLA-DRB1, -DQA1 and -DQB1) with serum levels of cytokines interleukin (IL)-6, tumor necrosis factor-α (TNF-α), IL-10 and IL-17 as well as risks of HPV infections, lesions and CC among admixed Brazilian women. HLA polymorphisms were associated with an increased risk or protection from HPV, lesions and CC. Additionally, we demonstrated a potential association of a HLA class I haplotype (HLA-B*14-C*08) with higher IL-10 cytokine serum levels in cervical disease, suggesting an association between HLA class I and specific cytokines in cervical carcinogenesis. However, larger studies with detailed HPV types coupled with genetic data are needed to further evaluate the effects of HLA and CC by HPV genotype.
Databáze: OpenAIRE
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