Evaluation of Virulence Factors and Antifungal Susceptibility in Yeast Isolates from Postmortem Specimens
| Autor: | Nihan Ziyade, Nuri Kiraz, Hafize Sav, Sümeyye Şen, Yalcin Buyuk, Yusuf Atan, Neval Elgormus, Esma Akkoyun Bilgi, Gulhan Yagmur |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cryptococcus neoformans Antifungal Agents Virulence Factors 030106 microbiology Virulence Drug resistance Biology medicine.disease biology.organism_classification Yeast Corpus albicans Pathology and Forensic Medicine Microbiology Fungicide 03 medical and health sciences Mycoses Cryptococcosis Genetics medicine Humans Autopsy Candida albicans Candida |
| Zdroj: | Journal of Forensic Sciences. 61:1000-1006 |
| ISSN: | 0022-1198 |
| DOI: | 10.1111/1556-4029.13089 |
| Popis: | Invasive fungal infections are a leading cause of morbidity and mortality in immunocompromised patients, especially in cases requiring a prolonged stay in the intensive care unit. A total of 99 yeast strains were isolated from 42 postmortem cases. In this study, virulence factors and antifungal susceptibility of these species were evaluated. The isolates were identified as Candida albicans (54), C. tropicalis (15), C. glabrata (12), C. parapsilosis (6), C. lipolytica (3), C. utilis (3), C. krusei (2), C. kefyr (1), and Cryptococcus neoformans (3). The most commonly isolated species was C. albicans, and no resistant species were determined. Despite the equal number of specimens, no secretion of significant virulence factors was associated with the postmortem specimen in the Candida species. Postmortem fungal investigations in forensic autopsies are useful in explaining cause of death in such cases, also may lead to protocols for the treatment of fungal infections and contribute to fungal pathogenesis and epidemiological data. |
| Databáze: | OpenAIRE |
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