Usefulness of whole body FDG18 PET-CT imaging in comprehensive oncologic management - initial experience
| Autor: | Manas T Mayank, Ashish S Kumar, Mayur V Kandedia, Yogesh M Mistry |
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| Rok vydání: | 2010 |
| Předmět: |
Systemic disease
medicine.diagnostic_test business.industry Planning target volume Regional Disease Pet ct imaging General Medicine medicine.disease Oncology Positron emission tomography Neoplasms Positron-Emission Tomography Imrt planning Humans Medicine Radiology Nuclear Medicine and imaging Radiotherapy treatment Tomography X-Ray Computed Whole body Nuclear medicine business |
| Zdroj: | Journal of Cancer Research and Therapeutics. 6:290 |
| ISSN: | 0973-1482 |
| DOI: | 10.4103/0973-1482.73362 |
| Popis: | Aims: Retrospective analysis of outcome with PET-CT imaging used for various clinical situations. Materials and Methods: Whole body PET-CT scan of 29 patients was evaluated. In first group, PET-CT was used for response evaluation after curative radio-chemotherapy. In second group, PET-CT was used as an additional diagnostic tool. In third group, PET-CT was used for delineating target volume. For first and second group, uptake was recorded with respect to primary, regional and distant site of involvement and confirmed through PET-CT guided biopsies whenever required. For third group, hypermetabolic volume delineated on PET image was compared with gross target volume delineated on CT image. Results: In first group, 50 % (6/12) of the patients had distant systemic disease, 33% (4/12) had residual regional disease and 58% (7/12) had residual/recurrent local disease. In second group, 30% (3/10) patients had distant systemic disease on PET-CT where CT was inconclusive. 25% (4/10) had variable extent of disease involvement on PET-CT that changed the technique of radiotherapy treatment. In 20% (2/10) patients, PET-CT changed the sequence of treatment. In third group (n=7), PET delineated volume was significantly higher (10-50%) than CT delineated volume for local site but for regional targets the difference was Conclusions: With the initial use of FDG18 PET-CT imaging, we realized that rate of distant metastasis is much higher which usually remain unnoticed because of conventional approach of investigation. PET-CT imaging has potential to improve the method of conventional IMRT planning. |
| Databáze: | OpenAIRE |
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