Chromosomal numerical abnormalities in early stage lung adenocarcinoma
| Autor: | Hisaki Igarashi, Haruhiko Sugimura, Koji Okudela, Yasuhiko Kitayama, Masaya Suzuki, Kingo Chida, Takehisa Sano, Fumihiko Tanioka |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lung Neoplasms Aneuploidy Biology Adenocarcinoma medicine.disease_cause Pathology and Forensic Medicine Sex Factors medicine Carcinoma Humans Atypical adenomatous hyperplasia Lung cancer In Situ Hybridization Fluorescence Aged Chromosome Aberrations Lung medicine.diagnostic_test Smoking General Medicine Middle Aged medicine.disease medicine.anatomical_structure Female Carcinogenesis Precancerous Conditions Fluorescence in situ hybridization |
| Zdroj: | Pathology international. 56(3) |
| ISSN: | 1320-5463 |
| Popis: | Chromosomal numerical abnormalities (CNA) are ubiquitous in human cancers. However, the question of when a CNA occurs in the course of tumor generation and progression, is controversial. Recent radiological scrutiny has enabled the identification of small peripheral lesions in the lung. A chromosome-wide investigation encompassing almost all the chromosomal centromeres was performed using modified fluorescence in situ hybridization on the archived pathological samples of 16 atypical adenomatous hyperplasia (AAH) and 30 lung adenocarcioma (AdCa) specimens including those smaller than 1 cm in size. The prevalence of the gain was more extensive in male than in female patients, and in non-smokers than in smokers. It tended to be greater in poorly differentiated AdCa, in moderately differentiated AdCa, and in well-differentiated AdCa cases, in that order. Most AAH had non-specific gains affecting all the examined chromosomes. The prevalence of the gain differed significantly between AAH and bronchioloalveolar carcinoma (BAC)/= 1 cm, but not between BAC1 cm and well-differentiated AdCa1 cm. It is proposed that the CNA is a distinct phenomenon occurring in the early or premalignant stage of lung AdCa, and that the CNA itself may not be a sequel in the carcinogenetic process, but a driving factor in carcinogenesis. |
| Databáze: | OpenAIRE |
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