Biomarkers of oxidative stress in babies at high risk for retinopathy of prematurity
| Autor: | Serafina Perrone, Stefano Martinelli, Mariangela Longini, Piero Vezzosi, Barbara Marzocchi, Patrizia Paffetti, Giuseppe Buonocore, Carlo Valerio Bellieni |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pediatrics
medicine.medical_specialty Newborn infants Birth weight Enzyme-Linked Immunosorbent Assay Free radicals medicine.disease_cause General Biochemistry Genetics and Molecular Biology Statistics Nonparametric Retinopathy of prematurity Cohort Studies Risk Factors Oxygen breathing medicine Birth Weight Humans Prospective Studies Prospective cohort study Chromatography High Pressure Liquid Analysis of Variance General Immunology and Microbiology business.industry Incidence (epidemiology) Delivery room Infant Newborn medicine.disease eye diseases Oxygen Oxidative stress business Perinatal period Biomarkers |
| Zdroj: | Europe PubMed Central Scopus-Elsevier |
| Popis: | Oxygen-induced oxidative stress (OS) has damaging effects in the perinatal period. For now there is a lake of evidence that OS occurs in babies with retinopathy of prematurity (ROP) We tests the hypothesis that a strict oxygen policy may minimize postnatal OS reducing severity of ROP. Multicenter prospective cohort study (72 newborns), using a common clinical management protocol with a strict control of oxygen administration. Assessment of biochemical markers of OS in blood samples at birth and on days 7, 14, and 21. Sixteen babies (22.2 per cent) developed ROP stage 1-2. No severe form of ROP was observed. Birth weight and O2 administration in delivery room were the factors significantly associated with the development of ROP stage 1-2. Prematurity and O2 administration in delivery room are the main factors coming into play in the course of ROP. Because room air is richer in oxygen than intrauterine environment, higher OS can be minimized, as well as incidence and severity of ROP, using standardized management with a restricted oxygen breathing policy. |
| Databáze: | OpenAIRE |
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