Med1 deficiency alters the somatic hypermutation spectrum in murine B cells
| Autor: | Vincent Heyer, Bernardo Reina-San-Martin, Ebe Schiavo, Léa Gaudot, Anne-Sophie Thomas-Claudepierre, Isabelle Robert |
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| Přispěvatelé: | Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
[SDV.IMM] Life Sciences [q-bio]/Immunology Protein subunit Immunology Somatic hypermutation Mice Transgenic Biology MED1 Mediator Complex Subunit 1 Mice 03 medical and health sciences Mediator Transcription (biology) Activation-induced (cytidine) deaminase medicine Animals Immunology and Allergy Mutation frequency B cell B-Lymphocytes Germinal Center Cell biology 030104 developmental biology medicine.anatomical_structure biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Somatic Hypermutation Immunoglobulin |
| Zdroj: | European Journal of Immunology European Journal of Immunology, 2018, 48 (4), pp.720-723. ⟨10.1002/eji.201747258⟩ |
| ISSN: | 1521-4141 |
| Popis: | The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation. Nevertheless, the mutation frequency at A residues is decreased and the expected A/T ratio is abolished, implicating Mediator in the second phase of somatic hypermutation. |
| Databáze: | OpenAIRE |
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