Serum eosinophil cationic protein (ECP) in human immunodeficiency virus (HIV) infection
| Autor: | Ivano Mezzaroma, Fernando Aiuti, Roberto Paganelli, D. Carmini, E Fanales-Belasio, Elena Pinter, Enrico Scala |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Immunology
Immunoglobulins HIV Infections Biology Immunoglobulin E Asymptomatic Atopy Ribonucleases White blood cell HIV Seropositivity medicine Humans Immunology and Allergy Eosinophil cationic protein Hypergammaglobulinemia Bacterial Infections Blood Proteins Eosinophil Granule Proteins medicine.disease Eosinophils medicine.anatomical_structure Virus Diseases HIV-1 biology.protein Viral disease medicine.symptom Antibody |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/0091-6749(91)90107-y |
| Popis: | HIV infection is immunologically characterized by progressive decrease of CD4’ lymphocytes and hypergammaglobulinemia. 1 Clinically, it spans from asymptomatic infection to full-blown AIDS, divided into definite stages by the Center for Disease Control classification.* A high incidence of atopic manifestations has been reported in HIV seropositive individuals3* ’ with increased serum levels of IgE.5 Recently, the rise of serum IgE has been related to the decrease of CD4+ cells.6 We selected 22 HIV seropositive subjects at different stages of disease, who presented allergic symptoms either for the first time or as a reexacerbation of previous atopic disease. In their sera, we measured the levels of total IgE, allergen-specific IgE, and ECP, a basic protein with cytotoxic properties released by EOSs, which is increased in sera and secretions of atopic patients.‘.’ As control subjects, we chose 25 healthy nonatopic subjects, 20 patients with acute recurrent infection (both bacterial and viral), and 29 HIV seropositive cases without history or present symptoms of atopy. Care was taken to match the HIV groups for age, sex, and disease stages. Detailed data on the composition of the groups are reported in Table I. Additional tests in HIV-positive subjects were white blood cell count, EOS count, both by standard methods, CD4’ lymphocyte count, with direct immunofluorescence with monoclonal anti-CD4 (OKT4, Ortho Diagnostic Systems, Raritan, N . J .) and read by flow cytometry (Cytoron, Ortho Diagnostic Systems), and serum levels of IgG, IgA, and IgM by nephelometry with a TDX analyzer (Abbott Diagnostics, Irving, Texas). Results of serum levels of IgE, mea |
| Databáze: | OpenAIRE |
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