Symptom validity testing in memory clinics: Hippocampal-memory associations and relevance for diagnosing mild cognitive impairment

Autor: Jos F. M. de Jonghe, Pauline E.J. Spaan, G. J. M. Walstra, Silvia D. Olabarriaga, Anne Rienstra, Paul F. C. Groot, Ben Schmand, Aart J. Nederveen, Willem A. van Gool, Vladimir Korkhov, Charles B. L. M. Majoie
Přispěvatelé: Faculteit der Geneeskunde, Brein en Cognitie (Psychologie, FMG), Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, Neurology, Amsterdam Public Health, Epidemiology and Data Science, Amsterdam Movement Sciences
Rok vydání: 2013
Předmět:
Male
Malingering
050103 clinical psychology
medicine.medical_specialty
Neuropsychological Tests
Audiology
Hippocampal formation
Hippocampus
03 medical and health sciences
0302 clinical medicine
Test of Memory Malingering
Memory
Image Processing
Computer-Assisted
medicine
Humans
Dementia
Cognitive Dysfunction
0501 psychology and cognitive sciences
Cognitive impairment
Aged
Psychiatric Status Rating Scales
Memory Disorders
medicine.diagnostic_test
Mental Disorders
05 social sciences
Memory clinic
Reproducibility of Results
Recognition
Psychology
Magnetic resonance imaging
Neuropsychological test
Middle Aged
Verbal Learning
medicine.disease
Magnetic Resonance Imaging
Diagnostic and Statistical Manual of Mental Disorders
Clinical Psychology
Neurology
Data Interpretation
Statistical
Mental Recall
Female
Neurology (clinical)
Verbal memory
Psychology
Psychomotor Performance
030217 neurology & neurosurgery
Clinical psychology
Zdroj: Journal of Clinical and Experimental Neuropsychology, 35(1), 59-70. Taylor and Francis Ltd.
Journal of Clinical and Experimental Neuropsychology
Journal of clinical and experimental neuropsychology, 35(1), 59-70. Taylor and Francis Ltd.
ISSN: 1744-411X
1380-3395
Popis: Patients with mild cognitive impairment (MCI) do not always convert to dementia. In such cases, abnormal neuropsychological test results may not validly reflect cognitive symptoms due to brain disease, and the usual brain-behavior relationships may be absent. This study examined symptom validity in a memory clinic sample and its effect on the associations between hippocampal volume and memory performance. Eleven of 170 consecutive patients (6.5%; 13% of patients younger than 65 years) referred to memory clinics showed noncredible performance on symptom validity tests (SVTs, viz. Word Memory Test and Test of Memory Malingering). They were compared to a demographically matched group (n = 57) selected from the remaining patients. Hippocampal volume, measured by an automated volumetric method (Freesurfer), was correlated with scores on six verbal memory tests. The median correlation was r = .49 in the matched group. However, the relation was absent (median r = -.11) in patients who failed SVTs. Memory clinic samples may include patients who show noncredible performance, which invalidates their MCI diagnosis. This underscores the importance of applying SVTs in evaluating patients with cognitive complaints that may signify a predementia stage, especially when these patients are relatively young.
Databáze: OpenAIRE
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