Symptom validity testing in memory clinics: Hippocampal-memory associations and relevance for diagnosing mild cognitive impairment
Autor: | Jos F. M. de Jonghe, Pauline E.J. Spaan, G. J. M. Walstra, Silvia D. Olabarriaga, Anne Rienstra, Paul F. C. Groot, Ben Schmand, Aart J. Nederveen, Willem A. van Gool, Vladimir Korkhov, Charles B. L. M. Majoie |
---|---|
Přispěvatelé: | Faculteit der Geneeskunde, Brein en Cognitie (Psychologie, FMG), Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, Neurology, Amsterdam Public Health, Epidemiology and Data Science, Amsterdam Movement Sciences |
Rok vydání: | 2013 |
Předmět: |
Male
Malingering 050103 clinical psychology medicine.medical_specialty Neuropsychological Tests Audiology Hippocampal formation Hippocampus 03 medical and health sciences 0302 clinical medicine Test of Memory Malingering Memory Image Processing Computer-Assisted medicine Humans Dementia Cognitive Dysfunction 0501 psychology and cognitive sciences Cognitive impairment Aged Psychiatric Status Rating Scales Memory Disorders medicine.diagnostic_test Mental Disorders 05 social sciences Memory clinic Reproducibility of Results Recognition Psychology Magnetic resonance imaging Neuropsychological test Middle Aged Verbal Learning medicine.disease Magnetic Resonance Imaging Diagnostic and Statistical Manual of Mental Disorders Clinical Psychology Neurology Data Interpretation Statistical Mental Recall Female Neurology (clinical) Verbal memory Psychology Psychomotor Performance 030217 neurology & neurosurgery Clinical psychology |
Zdroj: | Journal of Clinical and Experimental Neuropsychology, 35(1), 59-70. Taylor and Francis Ltd. Journal of Clinical and Experimental Neuropsychology Journal of clinical and experimental neuropsychology, 35(1), 59-70. Taylor and Francis Ltd. |
ISSN: | 1744-411X 1380-3395 |
Popis: | Patients with mild cognitive impairment (MCI) do not always convert to dementia. In such cases, abnormal neuropsychological test results may not validly reflect cognitive symptoms due to brain disease, and the usual brain-behavior relationships may be absent. This study examined symptom validity in a memory clinic sample and its effect on the associations between hippocampal volume and memory performance. Eleven of 170 consecutive patients (6.5%; 13% of patients younger than 65 years) referred to memory clinics showed noncredible performance on symptom validity tests (SVTs, viz. Word Memory Test and Test of Memory Malingering). They were compared to a demographically matched group (n = 57) selected from the remaining patients. Hippocampal volume, measured by an automated volumetric method (Freesurfer), was correlated with scores on six verbal memory tests. The median correlation was r = .49 in the matched group. However, the relation was absent (median r = -.11) in patients who failed SVTs. Memory clinic samples may include patients who show noncredible performance, which invalidates their MCI diagnosis. This underscores the importance of applying SVTs in evaluating patients with cognitive complaints that may signify a predementia stage, especially when these patients are relatively young. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |