Comparison of Functional Capacity and Symptoms of COPD Patients with and without Pulmonary Hypertension
| Autor: | Omer Araz, Elif Yilmazel Ucar, Kamuran Kalkan, Fikriye Kalkan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
COPD
medicine.medical_specialty lcsh:R5-920 business.industry VO2 max General Medicine 030204 cardiovascular system & hematology medicine.disease Pulmonary hypertension Pulmonary function testing respiratory tract diseases 03 medical and health sciences 0302 clinical medicine 030228 respiratory system Internal medicine Statistical significance medicine Cardiology Original Article Complication business lcsh:Medicine (General) Survival rate Respiratory minute volume |
| Zdroj: | Eurasian J Med Eurasian Journal of Medicine, Vol 52, Iss 2, Pp 166-170 (2020) |
| ISSN: | 1308-8734 |
| Popis: | OBJECTIVE: Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD) associated with a decrease in the survival rate of patients with COPD. Our aim was to investigate whether PH impairs the functional capacity and symptoms in patients with COPD. In addition, we aimed to evaluate the correlation between the functional capacity and symptoms score in patients with COPD. MATERIALS AND METHODS: This prospective cross-sectional study enrolled 64 patients with moderate to severe COPD, prospectively. All patients underwent the pulmonary function test, echocardiography, 6-minute walk test (6MWT), and cardiopulmonary exercise testing (CPET). We applied the modified Medical Research Council (mMRC) dyspnea scale and COPD Assessment Test (CAT) to all patients. The mean pulmonary arterial pressure (mPAP) >30 mmHg with echocardiography was considered as PH. The patients were grouped according to the presence of PH as COPD-PH (n=30) and COPD-nonPH (n=34). RESULTS: Hospitalization rate was higher in the COPD-PH group than in the COPD-nonPH group (p=0.006). The 6MWT results were lower in the COPD-PH group compared to the COPD-nonPH group (325±61 m vs. 354±46 m, respectively, p=0.025). In the COPD-PH group, the maximum oxygen consumption (VO(2max)) was lower, but the difference did not reach statistical significance (p=0.118). Although the maximum load and minute ventilation were lower in the COPD-PH group, the end-tidal pressure of CO(2) (PETCO(2)) was higher (p=0.033, p=0.036, and p=0.009, respectively). However, the CAT score and mMRC were similar between the groups (p=0.405 and p=0.238, respectively). CONCLUSION: An elevated PAP in patients with COPD limits the exercise capacity. Using CPET in the functional evaluation of patients with COPD may be beneficial in the early detection of PH. |
| Databáze: | OpenAIRE |
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