Depletion of brain norepinephrine does not reduce spontaneous ambulatory activity of rats in the home cage
| Autor: | Robert W. Bonsall, Katherine A. Boss-Williams, Jay M. Weiss, Milburn S. Emery, James W. Murrough |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Period (gene) Central nervous system Motor Activity Injections Rats Sprague-Dawley Norepinephrine Prosencephalon Reference Values Internal medicine medicine Animals Circadian rhythm Oxidopamine Molecular Biology Injections Intraventricular Chemistry General Neuroscience Housing Animal Circadian Rhythm Rats medicine.anatomical_structure Endocrinology Ventricle Anesthesia Ambulatory Forebrain Catecholamine Sympatholytics Neurology (clinical) Developmental Biology medicine.drug |
| Zdroj: | Brain research. 883(1) |
| ISSN: | 0006-8993 |
| Popis: | 6-Hydroxydopamine (6-OHDA) lesions of brain noradrenergic neurons and terminals were made in rats to assess the importance of forebrain norepinephrine (NE) for mediating circadian patterns of spontaneous ambulatory activity that rats show in the home cage. 6-OHDA was injected intracranially into the fibers of the ascending noradrenergic dorsal and ventral bundle pathways or infused into the lateral ventricle or both. Rats living in a 12/12 h light/dark cycle exhibit a marked increase in ambulatory activity during the dark period in comparison to the light period and a ‘W-shaped’ pattern of activity during the 12 h of the dark phase. Results showed that near-total depletion of brain NE did not impair the capacity to generate normal patterns of spontaneous ambulatory activity that occur in the home cage. In the animals that sustained the most complete NE lesions, the amounts of activity generated at times of peak activity were exaggerated in comparison to the control animals, which is consistent with the possibility that NE in the brain exerts a moderating influence on behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect