IRAK contributes to burn-triggered myocardial contractile dysfunction
| Autor: | D. Jean White, May F. Tsen, Jureta W. Horton, James A. Thomas |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Burn injury Cardiotonic Agents Lipopolysaccharide Physiology medicine.medical_treatment Biology Contractility chemistry.chemical_compound Mice Reference Values Physiology (medical) Internal medicine medicine Animals Kinase Heart Intracellular Membranes medicine.disease Myocardial Contraction Endocrinology Cytokine Interleukin-1 Receptor-Associated Kinases chemistry Heart failure Circulatory system Female Signal transduction Cardiology and Cardiovascular Medicine Burns Protein Kinases Signal Transduction |
| Zdroj: | American journal of physiology. Heart and circulatory physiology. 283(2) |
| ISSN: | 0363-6135 |
| Popis: | Major burn injury causes myocardial contractile dysfunction, but the molecular basis of this physiological response is incompletely understood. Previous studies demonstrated a role for the interleukin-1 receptor-associated kinase (IRAK) in the cardiac response to acute lipopolysaccharide administration as well as congestive heart failure. In this study, we examined the contribution of IRAK to burn-mediated cardiac responses. After burn injury, hearts from wild-type and IRAK-deficient mice were compared for intracellular signaling pathway activation and contractile function. IRAK-deficient hearts showed impaired activation of kinases that function downstream of IRAK and were partially protected against burn-induced contractile dysfunction. The findings demonstrate that IRAK and the Toll/interleukin-1 pathways participate in the response to large body surface area burns that leads to impaired cardiac contractility. |
| Databáze: | OpenAIRE |
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