Trypanocidal activity of lipophilic diamines and amino alcohols
| Autor: | M. Le Hyaric, Carlos A. M. Rezende, M. V. de Almeida, Heveline Silva, Ricardo José Alves, C.F. da Costa, Alvaro J. Romanha, Ana Paula Soares Fontes, Rosana O. Alves, Celso O. R. Junior |
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| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
Ethanol Dose-Response Relationship Drug Molecular Structure biology Chemistry Trypanosoma cruzi Biological activity General Medicine Diamines biology.organism_classification Amino Alcohols Trypanocidal Agents In vitro chemistry.chemical_compound Solubility Biochemistry Diamine parasitic diseases Lipophilicity Animals Gentian Violet Crystal violet IC50 |
| Zdroj: | Biomedicine & Pharmacotherapy. 64:624-626 |
| ISSN: | 0753-3322 |
| Popis: | Trypanocidal activity of a number of lipophilic diamines and amino alcohols was evaluated in vitro against Trypanosoma cruzi blood stream forms. Several of the studied compounds showed inhibition of T. cruzi growth. The most active ones were compounds 3, 4 and 5 with a IC₅₀ of 31.2 μg/mL, activity similar to the reference drug crystal violet. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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