Development and validation of a capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound

Autor:	Norbert G. F. M. Lammers, Thijs K. Gerding, Pim G. Muijselaar
Rok vydání:	2004
Předmět:	alpha-Cyclodextrins Chromatography Molecular Structure Chemistry Clinical Biochemistry Extraction (chemistry) Analytical chemistry Linearity Electrophoresis Capillary Stereoisomerism Biochemistry Analytical Chemistry Solutions Electrolytes Capillary electrophoresis Drug Stability Quinolines Enantiomer Antipsychotic Agents
Zdroj:	Electrophoresis. 25(16)
ISSN:	0173-0835
Popis:	A capillary electrophoresis method for the enantiomeric purity determination of SLV307, a basic potential antipsychotic compound, has been developed and validated. It is shown that the presence of the eutomer in the sample solution may have a significant effect on the peak shape of the distomer, due to electrodispersion. The method is shown to give good performance with respect to the validation parameters specificity, linearity, accuracy, precision, determination limits, stability of solutions, and robustness of extraction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb5691cd8431d326c9fd8f7cf639e8f https://pubmed.ncbi.nlm.nih.gov/15352019 Zobrazit plný text záznamu Plný text