The Role of ARV Associated Adverse Drug Reactions in Influencing Adherence Among HIV-Infected Individuals: A Systematic Review and Qualitative Meta-Synthesis

Autor: Meg Doherty, Rachel Beanland, Francoise Renaud, Mellanye Lackey, Marco Vitoria, Gifty Marley, Wei Ma, Joseph D. Tucker, Qingyan Ma, Chongyi Wei, Haochu Li
Rok vydání: 2016
Předmět:
Counseling
Cyclopropanes
0301 basic medicine
medicine.medical_specialty
Drug-Related Side Effects and Adverse Reactions
Social Psychology
Anti-HIV Agents
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Article
Medication Adherence
Poor adherence
03 medical and health sciences
0302 clinical medicine
immune system diseases
Hiv infected
Adaptation
Psychological
Humans
Medicine
030212 general & internal medicine
Drug reaction
Intensive care medicine
Psychiatry
Qualitative Research
health care economics and organizations
Meta synthesis
business.industry
Public health
Public Health
Environmental and Occupational Health
virus diseases
medicine.disease
030112 virology
Benzoxazines
Health psychology
Infectious Diseases
Alkynes
behavior and behavior mechanisms
business
Adverse drug reaction
Zdroj: AIDS and Behavior. 21:341-351
ISSN: 1573-3254
1090-7165
Popis: Poor adherence remains a major barrier to achieving the clinical and public health benefits of antiretroviral drugs (ARVs). A systematic review and qualitative meta-synthesis was conduct to evaluate how ARV adverse drug reactions may influence ARV adherence. Thirty-nine articles were identified, and 33 reported that ARV adverse drug reactions decreased adherence and six studies found no influence. Visually noticeable adverse drug reactions and psychological adverse reactions were reported as more likely to cause non-adherence compared to other adverse drug reactions. Six studies reported a range of adverse reactions associated with EFV-containing regimens contributing to decreased adherence. Informing HIV-infected individuals about ARV adverse drug reactions prior to initiation, counselling about coping mechanisms, and experiencing the effectiveness of ARVs on wellbeing may improve ARV adherence.
Databáze: OpenAIRE
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